Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I

Terpyridine platinum(II) complexes inhibit cysteine proteases by binding to active-site cysteine.

5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase

MEKKVLLTGFDPFGGETVNPSWEAVKRLNGAAEGPASIVSEQVPTVFYKSLAVLREAMKKHQPDIIICVGQAGGRMQITP
ERVAINLNEARIPDNEGNQPVGEDISQGGPAAYWTGLPIKRIVEEIKKEGIPAAVSYTAGTFVCNHLFYGLMDEISRHHP
HIRGGFIHIPYIPEQTLQKSAPSLSLDHITKALKIAAVTAAAHEDDIETGGGELHLEHHHHHH

1.8M sodium phosphate monobasic monohydrate, potassium phosphate dibasic, pH 6.9, VAPOR DIFFUSION, SITTING DROP, temperature 298K

MEKKVLLTGFDPFGGETVNPSWEAVKRLNGAAEGPASIVSEQVPTVFYKSLAVLREAIKKHQPDIIICVGQAGGRMQITP
ERVAINLNEARIPDNEGNQPVGEDISQGGPAAYWTGLPIKRIVEEIKKEGIPAAVSYTAGTFVCNHLFYGLMDEISRHHP
HIRGGFIHIPYIPEQTLQKSAPSLSLDHITKALKIAAVTAAVHEDDIETGGGELH