Structure of a domain-swapped FOXP3 dimer

Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.

Nuclear factor of activated T-cells, cytoplasmic 2

human IL-2 promoter ARRE2 site (plus strand)

human IL-2 promoter ARRE2 site (minus strand)

NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-ATp, T-cell transcription factor NFAT1

SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHA
FYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPE
SSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVAAAA
AAPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV

MRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRK
KR

(DT)(DT)(DA)(DG)(DG)(DA)(DA)(DA)(DA)(DT)(DT)(DT)(DG)(DT)(DT)(DT)(DC)(DA)(DT)(DA)
(DG)

(DA)(DA)(DC)(DT)(DA)(DT)(DG)(DA)(DA)(DA)(DC)(DA)(DA)(DA)(DT)(DT)(DT)(DT)(DC)(DC)
(DT)

5 mM HEPES, pH 7.63, 2 mM dithiothreitol (DTT), 0.5 mM EDTA, and 150 mM NaCl, VAPOR DIFFUSION, HANGING DROP, temperature 291K

The core hARRE2 site occurs naturally in humans.

Beta Barrel, Domain Swap, Forkhead Domain, Immnoglobulin Fold, Protein-DNA Complex, Double Helix, Transcription Regulation, DNA Binding, Nucleus, DNA BINDING PROTEIN-DNA complex

PLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQ
VHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSG
RIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQP
NMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV