Crystal structure of enoyl-coA hydratase EchA15 from Mycobacterium marinum in complex with an unknown ligand

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Increasing the structural coverage of tuberculosis drug targets.

GPGSMPLTYQDFPSLRFEPGEHGVLNLVLDSPGLNSVGPQMHRDLADVWPVIDRDPDVRVVLVRGEGKAFSSGGSFELID
ETIGDYEGRIRIMREARDLVLNLVNLDKPVVSAIRGPAVGAGLVVALLADISVASATAKIIDGHTKLGVAAGDHAAICWP
LLVGMAKAKYYLLTCETLSGEEAERIGLVSTCVDDDEVLPTATRLAENLAQGAQNAIRWTKRSLNHWYRMFGPTFETSLG
LEFLGFTGPDVQEGLAAHRQKRPARFTDRTEG

Internal tracking number 218997A9. JCSG screen condition A9: 20% PEG3350, 0.2 M ammonium chloride. MymaA.00829.b.A1 PS00862 at 43.78mg/ml., pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 290K

Seattle Structural Genomics Center for Infectious Disease

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

SSGCID, NIH, NIAID, SBRI, UW, Emerald BioStructures, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, LYASE

MPLTYQDFPSLRFEPGEHGVLNLVLDSPGLNSVGPQMHRDLADVWPVIDRDPDVRVVLVRGEGKAFSSGGSFELIDETIG
DYEGRIRIMREARDLVLNLVNLDKPVVSAIRGPAVGAGLVVALLADISVASATAKIIDGHTKLGVAAGDHAAICWPLLVG
MAKAKYYLLTCETLSGEEAERIGLVSTCVDDDEVLPTATRLAENLAQGAQNAIRWTKRSLNHWYRMFGPTFETSLGLEFL
GFTGPDVQEGLAAHRQKRPARFTDRTEG