Crystal structure of enoyl-coA hydratase from Mycobacterium avium

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Increasing the structural coverage of tuberculosis drug targets.

GPGSMVPVSHPPVDYHDFPSLRCELGDDGVLTVVLDSPGLNSVGPQMHRDLADIWPVIDRDPAVRAVLVRGEGKAFSSGG
SFDLIDETIGDYQGRIRIMREARDLVHNMINCDTPVVSAIRGPAVGAGLVVALLADISVAGRTAKLIDGHTKLGVAAGDH
AAICWPLLVGMAKAKYYLLTCETLLGEEAERIGLVSLCVDDDDVLSTAAGIAGKLAQGAQHAIQWTKRSLNHWYRMMGPT
FETSVGLEFLSFSGPDVQEGLAAHREKRAARFTGGSAT

MyavA00829eA1 3C protease cleaved PW28936 at 23.9 mg/mL against JCSG+ screen condition H3, 0.1 M BisTris pH 5.5, 25% PEG 3350 with 25% ethylene glycol as cryo-protectant, crystal tracking ID 216914h3., VAPOR DIFFUSION, SITTING DROP

Seattle Structural Genomics Center for Infectious Disease

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : RESIDUAL ONLY

Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, enoyl-CoA, hydratase, non-pathogenic species, mycobacterium, tuberculosis, fatty acid metabolism, acetyl CoA, LYASE

PVSHPPVDYHDFPSLRCELGDDGVLTVVLDSPGLNSVGPQMHRDLADIWPVIDRDPAVRAVLVRGEGKAFSSGGSFDLID
ETIGDYQGRVRIMREARDLVHNMINCDTPVVSAIRGPAVGAGLVVALLADISVAGRTAKLIDGHTKLGVAAGDHAAICWP
LLVGMAKAKYYLLTCETLLGEEAERIGLVSLCVDDDDVLSTAAGIAGKLAQGAQHAIQWTKRSLNHWYRTMGPTFETSVG
LEFLSFSGPDVQEGLAAHREKRAARFTGGSAT