Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: G1656D

Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.

Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation.

Breast cancer type 1 susceptibility protein

VNKRMSMVVSDLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKE
RKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVH
PIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIP

1.0M Li2SO4
100mM Tris
5mM CaCl2
10mM NiCl2

, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K

BRCA1 protein, Missense, phosphopeptide recognition, BRCT tandem repeats, Bach1 Ctip Abraxas, Nuclear Protein, PROTEIN BINDING

VNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKE
RKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVH
PIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIP