Thermotoga maritima DAH7P synthase in complex with inhibitor

Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis

Phospho-2-dehydro-3-deoxyheptonate aldolase

3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, DAHP synthase, Phospho-2-keto-3-deoxyheptonate aldolase

MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPED
TVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMY
VVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIR
TFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFK
ELVQEMKKLADALGVKVN

20%(w/v) polyethylene glycol 3350, 0.2M ammonium nitrate, 0.02%(w/v) sodium azide, VAPOR DIFFUSION, HANGING DROP, temperature 293.15K

Thermotoga maritima, DAH7PS, Shikimate pathway, aromatic biosynthesis, Tyr-bound, Tim barrel, act domain, ferredoxin-like domain, Transferase, Transferase-Transferase inhibitor complex, allosteric regulation