Crystal structure of Enoyl-CoA hydratase from Mycobacterium smegmatis

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Increasing the structural coverage of tuberculosis drug targets.

GPGSMADSPVLLVDTTDRVRTLTLNRPQSRNALSAELRSTFFRALSDAQNDDDVDVVIVTGADPVFCAGLDLKELGDTTE
LPDISPKWPDMTKPVIGAINGAAVTGGLELALYCDILIASENAKFADTHARVGLMPTWGLSVRLPQKVGVGLARRMSLTG
DYLSAQDALRAGLVTEVVAHDDLLTAARRVAASIVGNNQKAVRALLDSYHRIDALQTGGALWAEAEAARQWMRSTSGDDI
AASRASVIERGRSQVR

Internal tracking number 217319A12. PACT screen condition A12: 0.01 M ZnCl2, 0.1 M Na Oac pH 5, 20% PEG6000 MysmA.01566.a.A1 PW29040 at 25.27 mg/mL, vapor diffusion, sitting drop

Seattle Structural Genomics Center for Infectious Disease

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Emerald BioStructures, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, LYASE

MADSPVLLVDTTDRVRTLTLNRPQSRNALSAELRSTFFRALSDAQNDDDVDVVIVTGADPVFCAGLDLKELGDTTELPDI
SPKWPDMTKPVIGAINGAAVTGGLELALYCDILIASENAKFADTHARVGLMPTWGLSVRLPQKVGVGLARRMSLTGDYLS
AQDALRAGLVTEVVAHDDLLTAARRVAASIVGNNQKAVRALLDSYHRIDALQTGGALWAEAEAARQWMRSTSGDDIAASR
ASVIERGRSQVR