Crystal structure of the V130D mutant of OXA-24/40 in complex with doripenem

(4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
Doripenem(open form, pyrroline tautomer form 1, SP2 connection to Thio)

Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem.

The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem

Beta-lactamase OXA-33, Betalactamase OXA24, Carbapenem-hydrolyzing beta-lactamase OXA-40, Carbapenem-hydrolyzing oxacillinase, Class D beta-lactamase OXA-40, OXA-24 class D beta-lactamase, Oxa40

MHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKR
TYPMWEKDMTLGEAMALSADPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNR
LPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLE
NLGII

blaOXA-33, bla-OXA-40, blaOXA-24, blaOXA-40, oxa-24, oxa40

100 mM TRIS-HCl, 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K

The non-carbapenemase OXA-1 in complex with the same drug, doripenem.

Structure of the K84D mutant of OXA-24/40 in complex with doripenem

4J6 IN THE STRUCTURE REPRESENTS THE DELTA 2 TAUTOMER, IN WHICH A DOUBLE BOND IS PRESENT BETWEEN CARBONS 2 AND 3 (ATOMS CAS AND CAZ).

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

hydrolase, carbapenemase, HYDROLASE-ANTIBIOTIC complex

HISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRT
YPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRL
PFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLEN
LGII