Crystal structure of apo-caspase-6 at physiological pH

Crystal structures of active and inhibitor-bound human Casp6

MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSD
LGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFII
QACRGNQHDVPVIPLDVVD

DAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK
KQVPCFASMLTKKLHFFPKSNRHHHHHH

3.3 M sodium nitrate, 0.1 M Tris, 0.5 % ethyl acetate, 5 mM THP, pH 7.4, vapor diffusion, hanging drop, temperature 293K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : RESIDUAL ONLY

protease, Huntington's disease, mature apo-caspase-6, physiological pH, competitive inhibition, HYDROLASE

DAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGK
KQVPCFASMLTKKLHFFPKSN