Structure of an amyloid forming peptide KLVFFA from amyloid beta, alternate polymorph II
Molecular basis for amyloid-{beta} polymorphism.
KLVFFA hexapeptide segment from Amyloid beta
reservoir contained 30% (v/v) Jeffamine M-600, 0.1M Mes pH 6.5 ; 0.05M CsCl, 1mM FDDNP, vapor diffusion, hanging drop, temperature 291K
Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G
KLVFFA (residues 16-21) from Amyloid beta, synthesized
The biological unit is a pair of beta sheets. One sheet is constructed from two antiparallel strands (chain A and B) and unit cell translations along the b direction (i.e. X,Y+1,Z; X,Y+2,Z; X,Y+3,Z, etc.). The second sheet is constructed from -X,Y+1,-Z, -X,Y+2,-Z, -X,Y+3,-Z; etc. The crystal packing contains another interface between pairs of beta sheets; the second sheet is constructed from -X,Y+1,-Z+1, -X,Y+2,-Z+1, -X,Y+3,-Z+1; etc.
amyloid-like protofibril, PROTEIN FIBRIL