Structure of Giardia fructose-1,6-biphosphate aldolase in complex with 3-hydroxy-2-pyridone

({3-hydroxy-2-oxo-4-[2-(phosphonooxy)ethyl]pyridin-1(2H)-yl}methyl)phosphonic acid

Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase.

Putative fructose-1,6-bisphosphate aldolase

MPLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSRGALKYSDMIYLKKLCEAALEKHPDIPICI
HLDHGDTLESVKMAIDLGFSSVMIDASHHPFDENVRITKEVVAYAHARSVSVEAELGTLGGIEEDVQNTVQLTEPQDAKK
FVELTGVDALAVAIGTSHGAYKFKSESDIRLAIDRVKTISDLTGIPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIES
IVHAIGEGVCKINVDSDSRMAMTGAIRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSAGHAGDYKVVSLEEAKA
WYK

18-25% Polyethylglycol 3350, 0.2 M NH4NO3, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.0 K

Structure of Giardia fructose-1,6-biphosphate aldolase in complex with phosphoglycolohydroxamate

Structure of Giardia fructose-1,6-biphosphate aldolase

Structure of Giardia fructose-1,6-biphosphate aldolase in complex with 1,6-di-O-phosphono-D-fructose

Structure of Giardia fructose-1,6-biphosphate aldolase in complex with 1,6-di-O-phosphono-D-tagatose

Class II fructose-1, 6-bisphosphate aldolase, glycolytic pathway, LYASE