Crystal structure of benzamide 9 bound to AuroraA

Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.

cDNA FLJ58295, highly similar to Serine/threonine-protein kinase 6
AuroraA kinase domain (UNP residues 57 to 323)

KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAT
RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSS
RRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLL
KHNPSQRPMLREVLEHPWITANSSKPS

0.5 or 1.0 M LiCl,
12.5-25% PEG4000, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K