Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAAD
VAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD
IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE
LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQ
SMI

MgCl2, pH 7.4, hanging drop vapor diffusion, temperature 298K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

PHOSPHODIESTERASE, HYDROLASE-HYDROLASE INHIBITOR complex