Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter

Structure of a cation-bound multidrug and toxic compound extrusion transporter.

Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump

ENSVHRYKKEASNLIKLATPVLIASVAQTGMGFVDTIMAGGVSAIDMAAVSIAASIWLPSILFGVGLLMALVPVVAQLNG
AGRQHKIPFEVHQGLILALLVSVPIIAVLFQTQFIIRFMDVEEAMATKTVGYMHAVIFAVPAYLLFQALRSFTDGMSLTK
PAMVIGFIGLLLNIPLNWIFVYGKFGAPELGGVGCGVATAIVYWIMLLLLLFYIVTSKRLAHVKVFETFHKPQPKELIRL
FRLGFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVALNFSSLVFMFPMSIGAAVSIRVGHKLGEQDTKGAAIAANVG
LMTGLATACITALLTVLFREQIALLYTENQVVVALAMQLLLFAAIYQCMDAVQVVAAGSLRGYKDMTAIFHRTFISYWVL
GLPTGYILGMTNWLTEQPLGAKGFWLGFIIGLSAAALMLGQRLYWLQKQSDDVQLHLAAK

50mM Tris-HCl pH 7.2-8.6, 87 mM (NH4)2SO4, and 16-24% polyethylene glycol 250 dimethyl ether in D2O, VAPOR DIFFUSION, SITTING DROP, temperature 295K

HELIX
DETERMINATION METHOD: AUTHOR DETERMINED

MATE, multidrug transporter, cation-bound, TRANSPORT PROTEIN