Crystal structure of Plasmodium vivax putative farnesyl pyrophosphate synthase (Pv092040)

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.

GSSHHHHHHSSGRENLYFQGMKETNSEEADSGLAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGK
NNRGILVILIYEYVKNRDINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYN
SIYKLIEIYLRNESCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSDAHREIDVNNINVPEQPVIDINMINFGVYKNIVI
HKTAYYSFFLPIVCGMLLAGIAVDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFEL
CSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV

22% PEG 3350, 200 MM LI2SO4, 100 MM TRIS pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 297K

PLASMODIUM VIVAX FARNESYL PYROPHOSPHATE SYNTHASE, PV092040, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSFERASE, Isoprene biosynthesis

MKETNSEEADSGLAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNRDIN
SSEWEKAACLAWCIEILQAAFLVADDIMDKGETRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVI
ATFRDATLKTIIGQHLDTNIFSDKYSDAHREIDVNNINVPEQPVININMINFGVYKNIVIHKTAYYSFFLPIVCGMLLAG
IAVDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLAC
VKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILFTGV