Crystal structure of the E131K mutant of the Indian Hedgehog N-terminal signalling domain

MRGSHHHHHHGSCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEE
NTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTKGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGF
DWVYYESKAHVHCSVKSEHSAAAKTGG

0.1M sodium cacodylate, pH 6.5, 30% PEG 8000, 0.2M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 289K

the Indian Hedgehog N-terminal signalling domain, wild type

the E95K mutant of the Indian Hedgehog N-terminal signalling domain

the D100E mutant of the Indian Hedgehog N-terminal signalling domain

alpha+beta sandwich, Autocatalytic cleavage, Cell membrane, Developmental protein, Disease mutation, Glycoprotein, Hydrolase, Lipoprotein, Membrane, Palmitate, Protease, Secreted, SIGNALING PROTEIN

CGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRC
KDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVH
CSVKSEHSAAAKTGG