Crystal structure of human CD38 complexed with an analog ribo-2'F-ADP ribose

[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
ribosyl-2-fluoro-deoxy-adenosine diphosphate ribose; ribo-2'F-ADPR

Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase

extracellular domain, enzymatic domain, residues 45-300

CD38, Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10

KREAEARWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVP
CNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAE
AACDVVHVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNI
YRPDKFLQCVKNPEDSSCTSEI

100mM MES, pH 6.0, 15% PEG 4000, VAPOR DIFFUSION, HANGING DROP, temperature 298K

ADP-ribosyl cyclase complexed with 2F-ADPR and nicotinamide

ADP-ribosyl cyclase complexed with N1-cIDPR

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Enzyme-analog complex, covalent reaction intermediate, Alpha helices rich domain and alpha/beta domain, Diabetes mellitus, Disulfide bond, Glycoprotein, Hydrolase, Membrane, NAD, Receptor, Signal-anchor, Transmembrane

RWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILL
WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV
HVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF
LQCVKNPEDSSCTSEI