LVEALYL peptide derived from human insulin chain B, residues 11-17
Molecular basis for insulin fibril assembly.
20% MPD, 0.1M sodium citrate pH 5.5, vapor diffusion, hanging drop, temperature 298K
Residues 12-17 from the insulin B-chain.
HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
THE BIOLOGICAL UNIT IS A INDEFINITELY LONG PAIR OF SHEETS (A PROTOFIBRIL). ONE SHEET FORMED BY CHAIN A AND CRYSTALLOGRAPHIC TRANSLATIONS ALONG THE B CELL DIMENSION (E.G. X,Y,Z AND X,Y+1,Z). THE SECOND SHEET IS CONSTRUCTED FROM 1/2-X,1/2+Y,1-Z AND CRYSTALLOGRAPHIC TRANSLATIONS ALONG THE B CELL DIMENSION (E.G. 1/2-X,3/2+Y,1-Z).
amyloid-like protofibril, Carbohydrate metabolism, Cleavage on pair of basic residues, Diabetes mellitus, Disease mutation, Disulfide bond, Glucose metabolism, Hormone, Pharmaceutical, Secreted, PROTEIN FIBRIL