Crystal structure of human Intersectin 2 RhoGEF domain

MHHHHHHSSGRENLYFQGCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ
QWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKAL
RVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPM
QRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLE

25% PEG-3350, 0.1M ammonium sulfate, 0.1M Bis-Tris, 1:100 papain protease was added, SDS-PAGE indicated that the crystallized protein had a molecular weight of 23kDa, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K

AUTHOR DETERMINED BIOLOGICAL UNIT IS UNKNOWN.

Structural genomics consortium, guanine nucleotide exchange factor, SGC, SH3 DOMAIN, ENDOCYTOSIS

CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERK
RQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGD
ILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTP
ESHADHSSLKLALERAEELCSQVNEGVREKENSDRLE