NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form
Molecular mechanisms for protein-encoded inheritance
NVGSNTY heptapeptide segment from Islet Amyloid Polypeptide
0.1M HEPES pH 7.5, 25% PEG 3350, vapor diffusion, hanging drop, temperature 298K
HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
THE AUTHORS STATE THAT THE BIOLOGICAL UNIT IS A INDEFINITELY LONG PAIR OF SHEETS (A PROTOFIBRIL). ONE SHEET FORMED BY CHAIN A AND CRYSTALLOGRAPHIC TRANSLATIONS ALONG THE "B" CELL DIMENSION (E.G. X,Y,Z AND X,Y+1,Z). THE SECOND SHEET IS CONSTRUCTED FROM 1-X, Y+1/2,1-Z AND CRYSTALLOGRAPHIC TRANSLATIONS ALONG THE "B" CELL DIMENSION (E.G. 1-X, Y+3/2,1-Z). A SECOND BIOLOGICAL UNIT, SIMILAR TO THE FIRST, IS AN INDEFINITELY LONG PAIR OF SHEETS. ONE SHEET FORMED BY CHAIN B AND CRYSTALLOGRAPHIC TRANSLATIONS ALONG THE "B" CELL DIMENSION (E.G. X,Y,Z AND X,Y+1,Z). THE SECOND SHEET IS CONSTRUCTED FROM -X, Y+1/2,-Z AND CRYSTALLOGRAPHIC TRANSLATIONS ALONG THE "B" CELL DIMENSION (E.G. -X, Y+3/2,-Z).
amyloid-like protofibril, MEMBRANE PROTEIN, PROTEIN FIBRIL