Crystal structure of a trypanocidal 4,4'-Bis(imidazolinylamino)diphenylamine bound to DNA

Rosenbaum-Rock vertical focusing mirror, LN2 cooled first crystal, sagital focusing 2nd crystal

Rosenbaum-Rock high-resolution double-crystal

Reverse transcriptase domain: UNP residues 144-398

TWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLGIKPHIQRLLDQGILVPCQSPWNTPLLPVKK
PGTNDYRPVQDLREVNKRVEDIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWRDPEMGISGQL
TWTRLPQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAATSELDCQQGTRALLQTLGNLGYRASAKKAQICQ
KQVKYLGYLLKEGQR

PEG 4000, Magnesium acetate, ADA pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K

Two protein molecules joined by a 16mer-bp double strand of DNA, with CD27 bound to both 5'-AATT sites. One asymmetric unit retains one half of the 16mer-bp, one protein and one bound ligand.

TRANSFERASE/DNA MMLV RT, PROTEIN-DNA COMPLEX, DRUG-DNA COMPLEX, CD27, antitrypanosomal, DNA integration, DNA recombination, Nucleotidyltransferase, Transferase, TRANSFERASE-DNA complex