The crystal structure of EJC in its transition state

Mechanism of ATP turnover inhibition in the EJC

RNA-binding motif protein 8A, Ribonucleoprotein RBM8A, RNA-binding protein Y14, Binder of OVCA1-1, BOV-1

Eukaryotic translation initiation factor 4A isoform 3, ATP-dependent RNA helicase eIF4A-3, ATP-dependent RNA helicase DDX48, DEAD box protein 48, Eukaryotic initiation factor 4A-like NUK-34, Nuclear matrix protein 265, hNMP 265

Cancer susceptibility candidate gene 3 protein, Metastatic lymph node protein 51, Protein MLN 51, Protein barentsz, Btz

MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPP
DRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI

REDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVEYETYKEAQAA
MEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRRLE

MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIA
QSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVV
AGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL
VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIM
KEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQI
DEMPMNVADLILE

TKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGR
WEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHR

7% PEG 3350, 50mM Tris HCl pH 8.8, 200mM NaAcetate, VAPOR DIFFUSION, HANGING DROP, temperature 277K

PROTEIN-RNA COMPLEX, mRNA processing, mRNA splicing, mRNA transport, Nonsense-mediated mRNA decay, Nucleus, RNA-binding, Spliceosome, Transport, Alternative splicing, Cytoplasm, Phosphoprotein, Acetylation, ATP-binding, Helicase, Hydrolase, Nucleotide-binding, rRNA processing, Coiled coil, hydrolase-RNA binding protein-RNA COMPLEX

REDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVEYETYKEAQAA
MEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRR

MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIA
QSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVV
AGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL
VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIM
KEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQI
DEMPMNVADLI