Crystal structure of human CD38 extracellular domain E226Q mutant, NMN complex

Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.

Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10, CD38 antigen

KREAEARWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVP
CNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFATSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAE
AACDVVHVMLDGSRSKIFDKDSTFGSVQVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNI
YRPDKFLQCVKNPEDSSCTSEI

100 mM MES pH 6.0, 15% PEG 4000, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K

Human CD38 extracellular domain, ara-2-deoxy-2-fluoro-ribose-5'-phosphate complex

Human CD38 extracellular domain, ara-2-deoxy-2-fluoro-ribose-5'-phosphate/nicotinamide complex

Human CD38 extracellular domain, GTP complex

Human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex

Human CD38 extracellular domain, NMN complex

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

NMN complex, E226Q mutant, BETA SHEETS, ALPHA BUNDLE, Alternative splicing, Diabetes mellitus, Glycoprotein, Hydrolase, Membrane, NAD, Polymorphism, Receptor, Signal-anchor, Transmembrane

RWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILL
WSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVV
HVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKF
LQCVKNPEDSSCTSEI