CRE RECOMBINASE/DNA COMPLEX INTERMEDIATE I

Structure of the Holliday junction intermediate in Cre-loxP site-specific recombination.

Structure of Cre Recombinase Complexed with DNA in a Site-Specific Recombination Synapse

(DT)(DA)(DT)(DA)(DA)(DG)(DT)(DT)(DC)(DG)(DT)(DA)(DT)(DA)(DG)(DC)(DA)(DT)(DA)(DC)
(DA)(DT)(DT)(DA)(DT)(DA)(DC)(DG)(DA)(DA)(DT)(DT)(DT)(DA)(DT)

(DT)(DA)(DT)(DA)(DA)(DT)(DT)(DT)(DC)(DG)(DT)(DA)(DT)(DA)(DT)(DA)(DC)(DA)(DA)(DT)
(DG)(DC)(DT)(DA)(DT)(DA)(DC)(DG)(DA)(DA)(DC)(DT)(DT)(DA)(DT)

(DT)(DA)(DT)(DA)(DA)(DC)(DT)(DT)(DC)(DG)(DT)(DA)(DT)(DA)(DC)(DG)(DT)(DA)(DT)(DG)
(DT)(DA)(DT)(DA)(DT)(DA)(DC)(DG)(DA)(DA)(DA)(DT)(DT)(DA)(DT)

(DT)(DA)(DT)(DA)(DA)(DA)(DT)(DT)(DC)(DG)(DT)(DA)(DT)(DA)(DA)(DT)(DG)(DT)(DT)(DA)
(DC)(DG)(DT)(DA)(DT)(DA)(DC)(DG)(DA)(DA)(DG)(DT)(DT)(DA)(DT)

MSNLLTVHQNLPALPVDATSDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEPEDVRDYLLYLQA
RGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRRIRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRN
LAFLGIAYNTLLKIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTKLVERWISVSGVADDPNNYLFC
RVRKNGVAAPSATSQLSTRALEGIFEATHRLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNVNI
VMNYIRNLDSETGAMVRLLEDGD

50MM ACETATE PH 5.0, 26% MPD, 80MM MGCL2

THE STRUCTURE REPRESENTED IN THIS ENTRY CONTAINS TWO CRE MOLECULES AND FOUR DNA STRANDS. THE DNA IN THIS STRUCTURE HAS TWO-FOLD DISORDER IN THE 4 BP REGIONS ADJACENT TO THE BRANCH POINTS IN EACH A ARM AND IN SINGLE BASE PAIR LOCATED WITHIN THE CRE BINDING SITE. THE OCCUPANCIES OF ATOMS THESE DISORDERED REGIONS HAVE BEEN SET TO 0.5.

CRE RECOMBINASE, HOLLIDAY JUNCTION, RECOMBINATION, RECOMBINASE-DNA COMPLEX, HYDROLASE, LIGASE-DNA COMPLEX