Structural basis for NKG2A/CD94 recognition of HLA-E.

HLA class I histocompatibility antigen, alpha chain E

HLA class I histocompatibility antigen peptide
peptide presented by HLA-E (UNP residues 3-11)

NKG2-A/NKG2-B type II integral membrane protein

NK cell receptor, Killer cell lectin-like receptor subfamily D member 1, KP43

NKG2-A/B-activating NK receptor, NK cell receptor A, CD159a antigen

SHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTL
RGYYNQSEAGSHTLQWMHGCELGPDRRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLE
DTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTF
QKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRW

MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA
CRVNHVTLSQPKIVKWDRDM

CSCQEKWVGYRCNCYFISSEQKTWNESRHLCASQKSSLLQLQNTDELDFMSSSQQFYWIGLSYSEEHTAWLWENGSALSQ
YLFPSFETFNTKNCIAYNPNGNALDESCEDKNRYICKQQLI

ARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLSIISPSSWIGVFRNSSHHPWVTMNGL
AFKHEIKDSDNAELNCAVLQVNRLKSAQCGSSIIYHCKHK

1.8M ammonium sulfate, 0.3-0.7% sucrose, 100 mM Tris (8.0), VAPOR DIFFUSION, HANGING DROP, temperature 291K

peptide is naturally found in humans and was chemically synthesized.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

C-type lectin-like, Glycoprotein, Immune response, Membrane, MHC I, Transmembrane, Disease mutation, Glycation, Immunoglobulin domain, Pyrrolidone carboxylic acid, Secreted, Lectin, Receptor, Signal-anchor, IMMUNE SYSTEM

IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM