Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose

beta-D-galactose; D-galactose; galactose

Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans

N-terminal carbohydrate recognition domain

Gal-8, Po66 carbohydrate-binding protein, Po66-CBP, Prostate carcinoma tumor antigen 1, PCTA-1

MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSVKPRADVAFHFNPRFKRAGCIVCNT
LINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFS

0.275mM protein, 10mM Hepes-NaOH, 2.75mM lactose, 50mM sodium chloride, 0.5mM DTT, 50mM ammonium fluoride, 12% PEG 3350, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293.15K

The same protein complexed with lactose 3'-sulfate.

The same protein complexed with lactose sialic acid.

THIS RESIDUE IS CAUSED BY NATURAL VARIANT.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Beta-Sandwich, Galectin, Carbohydrate/Sugar Binding, Sugar Binding Protein

MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNT
LINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFS