Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Structure-Guided Evolution of Potent and Selective Chk1 Inhibitors Through Scaffold Morphing.

Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.

Design and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases.

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQ
YLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNR
ERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSG

STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY

DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION

IDENTIFICATION OF CHEMICALLY DIVERSE CHK1 INHIBITORS BY RECEPTOR-BASED VIRTUAL SCREENING

CRYSTAL STRUCTURE OF CHK1 WITH AN INDOL INHIBITOR

SYNTHESIS AND EVALUATION OF TRIAZOLONES AS CHECKPOINT KINASE 1 INHIBITORS

THE COMPLEX STRUCTURE OF CHECKPOINT KINASE CHK1/SB218078

DISCOVERY OF CHECKPOINT KINASE INHIBITOR AZD7762 BY STRUCTURE BASED DESIGN AND OPTIMIZATION OF THIOPHENE CARBOXAMIDE UREAS

THE COMPLEX STRUCTURE OF CHECKPOINT KINASE CHK1/UCN-01

IDENTIFICATION OF A BURIED POCKET FOR POTENT AND SELECTIVE INHIBITION OF CHK1: PREDICTION AND VERIFICATION

THE COMPLEX STRUCTURE OF CHECKPOINT KINASECHK1/ STAUROSPORINE

CRYSTAL STRUCTURE OF CHK1 COMPLEXED WITH A HYMENALDISINEANALOG

CO-CRYSTAL STRUCTURE OF CHECKPOINT KINASE CHK1 WITH APYRROLO-PYRIDINE INHIBITOR

THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINTKINASE CHK1