Structure of the regulatory fragment of mammalian aMPK in complex with two ADP

Structure of Mammalian Ampk and its Regulation by Adp

THE RESIDUES FROM A 393-395 AND 545-550 ARE ARTIFICIAL AS A RESULT OF CLONING STRATEGY.
5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1

5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2

5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1

AMPK GAMMA1, AMPK SUBUNIT GAMMA-1, AMPKG

MSHHHHHHSGLVPRGSMAWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSR
TYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFE
MCANLIKNSCTVN

MGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVT
TLLYKPI

MESVAAESAPAPENEHSQETPESNSSVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQS
FVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESG
NTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIY
SKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLEAIINRLVEAEVHRLVVVDEHDVVKGIVSLSDILQA
LVLTGGEKKP

GLYCOGEN-BINDING DOMAIN OF THE AMP-ACTIVATED PROTEIN KINASEBETA2 SUBUNIT

CRYSTAL STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEXES WITH AMP

CRYSTAL STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEXES WITH ATP-AMP

STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP

STRUCTURE OF AN ACTIVE FORM OF MAMMALIAN AMPK

CRYSTAL STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEXES WITH MG.ATP-AMP

STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH ONE ADP

THE DNA SEQUENCE WITH HIS-TAG, MSHHHHHHSGLVPRG AND THE ARTIFACTS, SMA (393-395) AND NSCTVN (545-550) B 186 METHIONINE IS AN ARTIFACT, CREATED BY CLONING.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

TRANSFERASE, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE