Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Design and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases.

Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQ
YLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNR
ERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSG

STRUCTURE-BASED DESIGN OF NOVEL CHK1 INHIBITORS: INSIGHTS INTO HYDROGEN BONDING AND PROTEIN-LIGAND AFFINITY

DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION

CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 ( CHK1) IN COMPLEX WITH INHIBITORS

IDENTIFICATION OF CHEMICALLY DIVERSE CHK1 INHIBITORS BY RECEPTOR-BASED VIRTUAL SCREENING

CRYSTAL STRUCTURE OF CHK1 WITH AN INDOL INHIBITOR

THE COMPLEX STRUCTURE OF CHECKPOINT KINASE CHK1/SB218078

THE COMPLEX STRUCTURE OF CHECKPOINT KINASE CHK1/UCN-01

IDENTIFICATION OF A BURIED POCKET FOR POTENT AND SELECTIVE INHIBITION OF CHK1: PREDICTION AND VERIFICATION

THE COMPLEX STRUCTURE OF CHECKPOINT KINASECHK1 /STAUROSPORINE

CRYSTAL STRUCTURE OF CHK1 COMPLEXED WITH A HYMENALDISINEANALOG

CO-CRYSTAL STRUCTURE OF CHECKPOINT KINASE CHK1 WITH APYRROLO-PYRIDINE INHIBITOR

THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINTKINASE CHK1

3-(1H-PYRAZOL-3-YL)-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,
2-A]PYRAZINE (XEZ): PYRAZOL-3-YL MAY BE MODELLED IN EITHER
ORIENTATION, CO-PLANAR WITH IMIDAZOPYRAZINE RING.

PYRAZOL-3-YL MOIETY CAN BE MODELED IN EITHER CO-PLANAR CONFORMATION.