The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with ADP and 1,3- bisphosphoglycerate

The Structure of Human Phosphoglycerate Kinase in its Fully Active Conformation in Complex with Ground State Analoges

PRIMER RECOGNITION PROTEIN 2, CELL MIGRATION-INDUCING GENE 10 PROTEIN, PRP 2

SLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPV
AVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVY
VNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMA
FTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESS
KKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLE
LLEGKVLPGVDALSNI

THE COMPLETE REACTION CYCLE OF HUMAN PHOSPHOGLYCERATE KINASE: THE OPEN TERNARY COMPLEX WITH 3PG AND ADP

THE STRUCTURE OF THE FULLY CLOSED CONFORMATION OF HUMAN PGK IN COMPLEX WITH L-ADP, 3PG AND THE TSA ALUMINIUM TETRAFLUORIDE

THE COMPLETE REACTION CYCLE OF HUMAN PHOSPHOGLYCERATE KINASE: THE OPEN BINARY COMPLEX WITH 3PG

THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE IN COMPLEX WITH ADP, 3PG AND MAGNESIUM TRIFLUORIDE

THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE IN COMPLEX WITH ADP, 3PG AND ALUMINIUM TETRAFLUORIDE

THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE K219A MUTANT IN COMPLEX WITH AMP-PCP AND 3PG

THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE K219A MUTANT IN COMPLEX WITH ADP, 3PG AND ALUMINIUM TRIFLUORIDE

THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE IN COMPLEX WITH ADP AND 3PHOSPHOGLYCERATE

THE COMPLETE REACTION CYCLE OF HUMAN PHOSPHOGLYCERATE KINASE: THE OPEN TERNARY COMPLEX WITH 3PG AND AMP-PNP

1,3-BISPHOSPHOGLYCERATE (X15): 1,3-BISPHOSPHOGLYCERATE WAS FORMED IN CRYSTALLO BY SOAKING CRYSTALS CONTAINING ADP AND 3PG IN ATP

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. 1,3-BISPHOSPHOGLYCERATE WAS FORMED IN THE CRYSTALS BY SOAKING ATP INTO CRYSTALS OF THE ADP 3PG COMPLEX.

TRANSITION STATE ANALOGUE, HEREDITARY HEMOLYTIC ANEMIA, PHOSPHOPROTEIN, KINASE, GLYCOLYSIS, TRANSFERASE, PHOSPHORYL TRANSFER, NUCLEOTIDE-BINDING

BINDING SITE FOR LINKED RESIDUES A 1419 A 1420 A 1421 A 1422