Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide

[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE

Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site.

EUKARYOTIC TRANSLATION INITIATION FACTOR 4E

EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1

MRNA CAP-BINDING PROTEIN, EIF-4F 25 KDA SUBUNIT, EIF-4E, EIF4E

P220, EIF-4-GAMMA 1, EIF-4G 1, EIF-4G1, EIF4GI

MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQ
LSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKG
DKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKKDKSKTWQANLRLISKFDTVEDFWALYNHIQ
LSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKG
DKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

60% AMMONIUM SULPHATE, 100MM TRIS-HCL PH 8.0, 1% PEG400

CRYSTALLOGRAPHIC AND MASS SPECTROMETRIC CHARACTERISATION OF EIF4E WITH N7-CAP DERIVATIVES

CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4ECOMPLEXED WITH 7-METHYL GTP

RECOGNITION OF EIF4G BY ROTAVIRUS NSP3 REVEALS A BASIS FORMRNA CIRCULARIZATION

CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4ECOMPLEXED WITH 7-METHYL GPPPA

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

PROTEIN BIOSYNTHESIS, INITIATION FACTOR, TRANSLATION REGULATION, TRANSLATION