Structure determination of Aurora Kinase in complex with inhibitor

Fragment-Based Discovery of the Pyrazol-4-Yl Urea (at9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity.

AURORA KINASE A, SERINE/THREONINE KINASE 15, AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, AURORA A, AURORA-A, AURORA-RELATED KINASE 1, HARK1

MESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF
HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVH
APSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKHHHHHH

CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE

STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA -739358

STRUCTURE OF HUMAN AURORA-A 122-403 PHOSPHORYLATED ON THR287, THR288

STRUCTURE OF UNPHOSPHORYLATED D274N MUTANT OF AURORA-A

AURORA-2 T287D T288D COMPLEXED WITH PHA- 680632

AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH A 5-AMINOPYRIMIDINYL QUINAZOLINE INHIBITOR

STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA -680626

STRUCTURE OF AURORA-A 122-403, PHOSPHORYLATED ON THR287, THR288 AND BOUND TO TPX2 1-43

AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP

CRYSTAL STRUCTURE OF AURORA-A PROTEIN KINASE

FRAGMENT-BASED DISCOVERY OF THE PYRAZOL-4- YL UREA (AT9283), A MULTI-TARGETED KINASE INHIBITOR WITH POTENT AURORA KINASE ACTIVITY

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, ATP-BINDING, POLYMORPHISM, PHOSPHOPROTEIN, KINASE, CANCER, AURORA, INHIBITOR, CELL CYCLE