CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR

Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines

TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1

PROTEIN-TYROSINE PHOSPHATASE 1B, PTP-1B, PROTEIN TYROSINE PHOSPHATASE 1B

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRS
YILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLEL
ENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPH
N

100 MM TRIS PH 8.5, 17% PEG 20, 000, 100 MM MAGNESIUM CHLORIDE

PROTEIN TYROSINE PHOSPHATASE 1B WITH SULFAMIC ACIDINHIBITORS

THE STRUCTURE OF THE S295F MUTANT OF HUMAN PTP1B

STRUCTURAL INSIGHTS INTO THE DESIGN OF NONPEPTIDIC ISOTHIAZOLIDINONE-CONTAINING INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B

STRUCTURAL OF PROTEIN TYROSINE PHOSPHATASE 1B (C2)

STRUCTURAL OF PROTEIN TYROSINE PHOSPHATASE 1B (P212121)

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH A TRI- PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR )RK) FROM THE INSULIN RECEPTOR KINASE

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 4

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH PHOSPHOTYROSINE- CONTAINING HEXA-PEPTIDE(DADEPYL-NH2)

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 3-(OXALYL-AMINO )-NAPHTHALENE-2-CARBOXLIC ACID

CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR

A HIGHLY EFFICIENT APPROACH TO A SELECTIVE AND CELL ACTIVEPTP1B INHIBITORS

POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINEPHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE,COMPLEXED WITH COMPOUND 19.

CRYSTAL STRUCTURE OF PTP1B WITH BICYCLIC THIOPHENE INHIBITOR

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 2-(OXALYL-AMINO )-4,5,6,7-TETRAHYDRO-THIENO[2,3-C] PYRIDINE-3-CARBOXYLIC ACID

OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 6-(OXALYL-AMINO )-1H-INDOLE-5-CARBOXYLIC ACID

1.95 A STRUCTURE OF APO PROTEIN TYROSINE PHOSPHATASE 1B

OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B,COMPOUND 8B

PTP1B COMPLEXED WITH ISOXAZOLE CARBOXYLIC ACID

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH PHOSPHOTYROSINE

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH A MONO- PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE

ALLOSTERIC INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B

CRYSTAL STRUCTURE OF THE PTP1B COMPLEXED WITH SP7343-SP7964,A PTYR MIMETIC

POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITORCOMPOUND 12 USING A LINKED- FRAGMENT STRATEGY

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2 -(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2, 3-C]PYRAN-3-CARBOXYLIC ACID

HUMAN TYROSINE PHOSPHATASE 1B COMPLEXED WITH AN INHIBITOR

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B WITHPOTENT AND SELECTIVE BIDENTATE INHIBITOR COMPOUND 2

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 9

CRYSTAL STRUCTURE OF PTP1B COMPLEXED WITH 7 -(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3- YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO- 5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID

STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 3

CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S ) MUTANT

PROTEIN TYROSINE PHOSPHATASE 1B WITH ACTIVE SITE INHIBITOR

OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B,COMPOUND 17

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH A BIS- PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL ) FROM THE INSULIN RECEPTOR KINASE

CRYSTAL STRUCTURE OF PTP1B WITH TRICYCLIC THIOPHENEINHIBITOR.

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH ACETYL-E-L-E- F-PTYR-M-D-Y-E-NH2

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXES WITH PNU179326

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH PHOSPHOTYROSINE- CONTAINING TETRA-PEPTIDE(AC-DEPYL-NH2)

MONOACID-BASED, CELL PERMEABLE, SELECTIVE INHIBITORS OFPROTEIN TYROSINE PHOSPHATASE 1B

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 5-IODO-2-( OXALYL-AMINO)-BENZOIC ACID

PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO A SULFENYL-AMIDE BOND

PTP1B R47C MODIFIED AT C47 WITH N-[4-(2 -{2-[3-(2-BROMO-ACETYLAMINO)-PROPIONYLAMINO ]-3-HYDROXY-PROPIONYLAMINO}-ETHYL)-PHENYL]- OXALAMIC ACID

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 2

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH TWO BIS(PARA- PHOSPHOPHENYL)METHANE (BPPM)MOLECULES

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN PTP1B AND THEINSULIN RECEPTOR TYROSINE KINASE

STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS

PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL- PHOSPHATEINTERMEDIATE

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 2-(OXALYL-AMINO )-BENZOIC ACID

STRUCTURE OF PTP1B IN COMPLEX WITH A PEPTIDICBISPHOSPHONATE INHIBITOR

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 2-(OXALYL-AMINO- 4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3- CARBOXYLIC ACID

POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITORCOMPOUND 5 USING A LINKED- FRAGMENT STRATEGY

DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1BINHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATEHEAD ON THE FIRST SITE

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 11

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177496

POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITORCOMPOUND 23 USING A LINKED- FRAGMENT STRATEGY

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 6

PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO SULFONIC ACID

CRYSTAL STRUCTURE OF THE C215D MUTANT OF PROTEIN TYROSINEPHOSPHATASE 1B

NON-CARBOXYLIC ACID-CONTAINING INHIBITOR OF PTP1B TARGETINGTHE SECOND PHOSPHOTYROSINE SITE

RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITYOF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH ACETYL-D-A-D- BPA-PTYR-L-I-P-Q-Q-G

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES

MEMBRANE, OXIDATION, HYDROLASE, ACETYLATION, PHOSPHATASE, POLYMORPHISM, PHOSPHORYLATION, PROTEIN PHOSPHATASE, ENDOPLASMIC RETICULUM