Crystal Structure of 2-Enoyl Thioester Reductase of Human FAS II

Structural Enzymological Studies of 2-Enoyl Thioester Reductase of the Human Mitochondrial Fas II Pathway: New Insights Into its Substrate Recognition Properties.

MASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGLLPELPAVGGNEGV
AQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQ
NASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSS
TELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVP
LQDYQSALEASMKPFISSKQILTM

2M AMMONIUM SULFATE, 100 MM TRIS HCL, PH 8.5

THE STRUCTURE OF HUMAN MITOCHONDRIAL 2-ENOYL THIOESTERREDUCTASE (CGI-63)

SHEET
THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN
ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW,
TWO SHEETS ARE DEFINED.

THIS CONSTRUCT DOES NOT CONTAIN MITOCHONDRIAL SIGNAL AND STARTS FROM RESIDUE ALA31.

RESIDUES 31-41 ARE NOT PRESENT IN THE STRUCTURE

NADP, POLYMORPHISM, MITOCHONDRION, OXIDOREDUCTASE, FATTY ACID BIOSYNTHESIS, ENOYL THIOESTER REDUCTASE, LIPID SYNTHESIS, TRANSIT PEPTIDE