Crystal structure of vaccinia virus thymidylate kinase bound to TDP

Crystal Structure of Poxvirus Thymidylate Kinase: An Unexpected Dimerization Has Implications for Antiviral Therapy

MSRGALIVFEGLDKSGKTTQCMNIMESIPANTIKYLNFPQRSTVTGKMIDDYLTRKKTYNDHIVNLLFCANRWEFASFIQ
EQLEQGITLIVDRYAFSGVAYAAAKGASMTLSKSYESGLPKPDLVIFLESGSKEINRNVGEEIYEDVTFQQKVLQEYKKM
IEEGDIHWQIISSEFEEDVKKELIKNIVIEAIHTVTGPVGQLWM

23% PEG 400, 100 MM NA ACETATE, 100 MM MES PH 6.5

CRYSTAL STRUCTURE OF VACCINIA VIRUS THYMIDYLATE KINASE BOUND TO BRIVUDIN-5'- MONOPHOSPHATE

THYMIDINE-5'-DIPHOSPHATE (TYD): ALTERNATE CONFORMATION WITH
POP 160
PYROPHOSPHATE (POP): ALTERNATE CONFORMATION WITH TYD 160

NUCLEOTIDE BIOSYNTHESIS, ATP-BINDING, NUCLEOTIDE-BINDING, KINASE, POXVIRUS, TMP KINASE, TRANSFERASE