Structure of the human receptor tyrosine kinase Met in complex with the Listeria monocytogenes invasion protein inlb: low resolution, Crystal form II

Structure of the Human Receptor Tyrosine Kinase met in Complex with the Listeria Invasion Protein Inlb

INTERNALIN DOMAIN (CAP, LRR, IR)\: INLB321, RESIDUES 36-321

SEMA, PSI, IG1, IG2\: MET741, RESIDUES 25-740

HGF RECEPTOR, SCATTER FACTOR RECEPTOR, SF RECEPTOR, HGF/SF RECEPTOR, MET PROTO-ONCOGENE TYROSINE KINASE, C-MET

GAMETITVPTPIKQIFSDDAFAETIKDNLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTD
IKPLANLKNLGWLFLDENKVKDLSSLKDLKKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKITDITVLSRLTKLDTLS
LEDNQISDIVPLAGLTKLQNLYLSKNHISDLRALAGLKNLDVLELFSQECLNKPINHQSNLVVPNTVKNTDGSLVTPEII
SDDGDYEKPNVKWHLPEFTNEVSFIFYQPVTIGKAKARFHGRVTQPLKE

ETRECKEALAKSEMNVNMKCQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDC
SSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALG
AKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYF
LTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDI
LFAVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFT
TALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGY
TLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRL
TICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITS
ISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYRED
LHHHHHH

VAPOR DIFFUSION AT 25 DEGREE C IN SITTING-DROPS. 2 UL PROTEIN (8 MG/ML)PLUS 2 UL RESERVOIR (1.4 M NA/K PHOSPHATE, PH 6.5, 10% PEG 2000 MONO-METHYL-ETHER)

DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTALSTRUCTURE OF THE GRB2-SH2 AC- PYVNV COMPLEX

INTERNALIN B: CRYSTAL STRUCTURE OF FUSED N- TERMINAL DOMAINS.

CRYSTAL STRUCTURE OF INTERNALIN B (INLB), A LISTERIAMONOCYTOGENES VIRULENCE PROTEIN CONTAINING SH3-LIKEDOMAINS.

CALCIUM-BINDING MUTANT OF THE INTERNALIN B LRR DOMAIN

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THEHEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITHTHE MICROBIAL ALKALOID K-252A

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THEHEPATOCYTE GROWTH FACTOR RECEPTOR C-MET

THE CRYSTAL STRUCTURE OF HGF BETA-CHAIN IN COMPLEX WITH THESEMA DOMAIN OF THE MET RECEPTOR.

SOLUTION STRUCTURE OF THE PSI DOMAIN FROM THE MET RECEPTOR

3D STRUCTURE PREDICTION OF AMINO ACIDS 25 TO 656 OF HUMAN HEPATOCYTE GROWTH FACTOR/ SCATTER FACTOR (MET) RECEPTOR

3D STRUCTURE PREDICTION OF THE IG2-IG4 DOMAINS OF THE ECTODOMAIN REGION OF THE HUMAN HEPATOCYTE GROWTH FACTOR-SCATTER FACTOR RECEPTOR, MET

STRUCTURAL CHARACTERIZATION OF AUTOINHIBITED C- MET KINASE

STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASE MET IN COMPLEX WITH THE LISTERIA MONOCYTOGENES INVASION PROTEIN INLB: CRYSTAL FORM I

SHEET
THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN
ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW,
TWO SHEETS ARE DEFINED.

MEDIATES THE ENTRY OF LISTERIA MONOCYTOGENES INTO CELLS. RECEPTOR FOR HEPATOCYTE GROWTH FACTOR AND SCATTER FACTOR
CHAIN A+C: RESIDUES 33-35 (GAM) REMAIN AFTER TEV CLEAVAGE CHAIN B+D: Y41C AND G344A PROBABLY DUE TO PCR ERROR. N-TERMINAL ETR LEFT AFTER PROCESSING OF IG-LEADER SEQUENCE. C-TERMINAL DLHHHHHH DUE TO CLONING AND HIS6 TAG.

B-FACTORS MODELED SOLELY BY TLS. TOTAL ISOTROPIC B-FACTORS GIVEN. TIGHT NCS ON INDIVIDUAL DOMAINS EMPLOYED THROUGHOUT.

SIGNALING PROTEIN/RECEPTOR, LEUCINE RICH REPEAT, RECEPTOR ECTODOMAIN, HEPATOCYTE GROWTH FACTOR RECEPTOR, ATP-BINDING, TRANSFERASE, POLYMORPHISM, GLYCOPROTEIN, VIRULENCE FACTOR, DISEASE MUTATION, NUCLEOTIDE-BINDING, TRANSMEMBRANE, PROTO-ONCOGENE, PHOSPHORYLATION, LEUCINE-RICH REPEAT, ALTERNATIVE SPLICING, TYROSINE-PROTEIN KINASE, CHROMOSOMAL REARRANGEMENT, LRR, HGFR, KINASE, MEMBRANE, RECEPTOR, INTERNALIN, SIGNALING PROTEIN-RECEPTOR COMPLEX