Crystal structure of the human FOXO3a-DBD bound to DNA

Crystal Structure of the Human Foxo3A-Dbd/DNA Complex Suggests the Effects of Post-Translational Modification.

FORKHEAD IN RHABDOMYOSARCOMA-LIKE 1, AF6Q21 PROTEIN

MGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWII
NPDGGKSGKAPRRRAVS

RESIDUES 157 AND 1157 ARE MET AND ALA, RESPECTIVELY. THESE TWO RESIDUES ARE GENERATED FORM VECTOR, NOT THE WILD TYPE FOXO3A AMINO ACIDS. THE SIDE CHAINS OF THESE RESIDUES 1242, 1243, 1245, 1246, AND 1247 IN CHAIN D ARE DISAPPEARED. GLY RESIDUES ARE SUBSTITUTED FOR THESE RESIDUES IN THIS MODEL. RESIDUES 1248-1253 IN CHAIN D ARE DISORDERED, AND NOT DETERMINED IN THE MODEL.

TRANSCRIPTION, TRANSCRIPTION REGULATION, CHROMOSOMAL REARRANGEMENT, ACTIVATOR, APOPTOSIS, DNA-BINDING, WINGED HELIX, PROTO-ONCOGENE, FORKHEAD TRANSCRIPTION FACTORS, NUCLEAR PROTEIN, PHOSPHORYLATION, DNA-BINDING DOMAIN