Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 33

Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors.

KINESIN-RELATED MOTOR PROTEIN EG5, KINESIN-LIKE SPINDLE PROTEIN HKSP, THYROID RECEPTOR-INTERACTING PROTEIN 5, TRIP-5, KINESIN-LIKE PROTEIN 1, KINESIN SPINDLE PROTEIN

MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQID
VYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSL
LEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRIL
QDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQK

100 MM BIS-TRIS (PH 6.0) 200 MM AMMONIUM SULFATE, AND 18-20% PEG3350. 10 MM SRCL2

CRYSTAL STRUCTURE OF THE MITOTIC KINESIN EG5 IN COMPLEXWITH MG-ADP.

CRYSTAL STRUCTURE OF THE MOTOR PROTEIN KSP IN COMPLEX WITHADP AND MONASTROL

HUMAN EG5 MOTOR DOMAIN BOUND TO MG-ADP AND MONASTROL

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 1

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 13

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 19

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 6

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH INHIBITOR 9H

CRYSTAL STRUCTURE OF THE MITOTIC KINESIN EG5 IN COMPLEXWITH MG-ADP AND N-(3- AMINOPROPYL)-N-((3-BENZYL-5-CHLORO-4-OXO- 3,4-DIHYDROPYRROLO[2,1-F][1,2,4] TRIAZIN-2-YL)(CYCLOPROPYL)METHYL)-4- METHYLBENZAMIDE

SHEET
THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN
ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW,
TWO SHEETS ARE DEFINED.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

KSP, EG5, COMPLEX, MITOSIS, THIOPHENE, INHIBITOR, NUCLEOTIDE-BINDING, KINESIN SPINDLE PROTEIN, MOTOR PROTEIN, CELL DIVISION, PHOSPHORYLATION, CELL CYCLE, MICROTUBULE, COILED COIL, ATP-BINDING