THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE

Structure of the Tet Repressor-Tetracycline Complex and Regulation of Antibiotic Resistance

ARLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRN
NAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPAA
PDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIV

REMAULT E.,STANSSENS P.,FIERS W. PLASMID VECTORS FOR HIGH-EFFICIENCY EXPRESSION CONTROLLED BY THE PL PROMOTER OF COLIPHAGE LAMBDA. GENE 15, 81-93 (1981).
PWH904 (K. TOVAR, PH.D. THESIS, UNIV. ERLANGEN-NUERNBERG, 1989)

ARLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRN
NAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPAA
PDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIVGGDKLIIPFC