Human EphA3 kinase domain, base structure

Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3).

GSTQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNII
RLEGVVTKSKPVMIVTE(PTR)MENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLV
CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDE
GYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDW
LNGVWTAHCKEIFTGVEYSSCDTIAKIS

GSTQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNII
RLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVS
DFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRL
PPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGV
WTAHCKEIFTGVEYSSCDTIAKIS

20 mg/mL Protein, 25% PEG 3350, 0.2M Ammonium sulfate, 0.1M Hepes, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K

The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region

Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure

Human EphA3 kinase and juxtamembrane region, dephosphorylated, AMP-PNP bound

Human EphA3 kinase and juxtamembrane region, phosphorylated, AMP-PNP bound

Human EphA3 kinase domain, phosphorylated, AMP-PNP bound structure

Human EphA3 kinase and juxtamembrane region, Y602F mutant

Human EphA3 kinase and juxtamembrane region, Y596F mutant

Human EphA3 kinase and juxtamembrane region, Y596F:Y602F double mutant

Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:S768A triple mutant

Human EphA3 kinase and juxtamembrane region, Y596:Y602:S768G triple mutant

Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:Y742A triple mutant

Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:Y742F triple mutant

Human EphA3 kinase and juxtamembrane region, base, AMP-PNP bound structure

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

receptor tyrosine kinase, structural genomics, Structural Genomics Consortium, SGC, ATP-binding, Membrane, Nucleotide-binding, Phosphorylation, Transferase, Transmembrane, Tyrosine-protein kinase

TQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRL
EGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDF
GLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPP
PMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWT
AHCKEIFTGVEYSSCDTIAKIS