Crystal Structure of an NSS Homolog with Bound Antidepressant

New York Consortium on Membrane Protein Structure (NYCOMPS)

Beta-Octylglucoside; octyl beta-D-glucoside; octyl D-glucoside; octyl glucoside

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.

REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLL
WRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPPNATDPDSILRPFKEFLYSYIGVPKGDEPILKP
SLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVW
IAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGF
ITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMD
FWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVW
ITRFYIIGLFLFLTFLVFLAERRRNHESAGT

PEG550 MME, NaCl, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K

New York Consortium on Membrane Protein Structure

The biological unit is the protein monomer in the asymmetric unit

neurotransmitter, transmembrane transport, integral membrane protein, antidepressant, NSS, TRANSPORT PROTEIN, Structural Genomics, PSI-2, Protein Structure Initiative, New York Consortium on Membrane Protein Structure, NYCOMPS

REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLL
WRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPPNATDPDSILRPFKEFLYSYIGVPKGDEPILKP
SLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVW
IAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGF
ITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMD
FWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVW
ITRFYIIGLFLFLTFLVFLAERRRNHESA