Solution Structure of ETO-TAFH refined in explicit solvent
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription
Protein CBFA2T1, Protein MTG8, Eight twenty one protein, Cyclin-D-related protein, Zinc finger MYND domain- containing protein 2
GARQLSKLKRFLTTLQQYGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLH CARLAKQNPAQYLAQHEQLLLDASTTS
RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
the structures are based on 1644 NOE-derived distance constraints, 236 dihedral angle restraints,m106 distance restraints from hydrogen bonds, and 96 residual dipolar coupling restraints
1.1 mM protein, 200 mM phosphate buffer, 95% H2O, 5% D2O
transcriptional cofactor, Leukemia, 4-helix bundle, TRANSCRIPTION
GARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLH CARLAKQNPAQYLAQHEQLLLDASTTS