The crystal structure of human synapsin III (SYN3) in complex with AMPPNP

PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

Actin-binding and synaptic-vesicle binding region

SMGLMEPPGPSTPIVQRPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKVV
SRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPN
HKPMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGN
WKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKM
SQLPMPGGTAPSPLRPWAPQIKSA

1.26M (NH4)2SO4, 0.2M Li2SO4, Tris-HCl pH 8.5, 20 % Ethylene glycol added as cryoprotectant, VAPOR DIFFUSION, SITTING DROP, temperature 293K

Swissmodel based on PDB entries: 1I7L, 1I7N, 1PK8

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Tetramer composed of chains A and B plus the 2 symmetry related chains generated by symmetry operator -X,Y,-Z

synapsin, neurotransmitter release, schizophrenia, vesicle transport, Structural Genomics, Structural Genomics Consortium, SGC, NEUROPEPTIDE

GLMEPPGPSTPIVQRPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKVVSR
SFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHK
PMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWK
ANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQ
LPMPGGTAPSPLRPWAPQIKSA