The APOBEC2 Crystal Structure and Functional Implications for AID

The APOBEC-2 crystal structure and functional implications for the deaminase AID.

GSGGGMIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVVEAQGKGGQVQASRGYLEDEHAAAHAEEAFFNTILPAFDPA
LRYNVTWYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQDFEYVWQNFVEQ
EEGESKAFQPWEDIQENFLYYEEKLADILK

85mM NaCitrate, 160mM LiSO4, 24% (wt/vol) PEG, 15% glycerol, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 291.15K

cytidine deaminase, zinc-ion binding, APOBEC, HYDROLASE

IVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVVEAQGKGGQVQASRGYLEDEHAAAHAEEAFFNTILPAFDPALRYNVT
WYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQDFEYVWQNFVEQEEGESK
AFQPWEDIQENFLYYEEKLADILK