Solution structure of the toxin ISTX-I from Ixodes scapularis
A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds.
blacklegged tick,deer tick,shoulder tick
1mM ISTX-I-1, 8mM ISTX-I-2, 10mM MES-3, 20mM sodium chloride-4, 90% H2O/10% D2O
Schwieters, Kuszewski, Tjandra and Clore