Competitive inhibition of TRPV1 calmodulin interaction by vanilloids
Capsaicin; 8-Methyl-N-vanillyl-trans-6-nonenamide; NGX-4010
Competitive inhibition of TRPV1-calmodulin interaction by vanilloids.
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTD SEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
back calculated data agree with experimental NOESY spectrum
60 uM [U-98% 13C; U-98% 15N] Calmodulin, 300 uM capsaicin, 90% H2O/10% D2O
60 uM [U-98% 13C; U-98% 15N] Calmodulin, 180 uM resiniferatoxin, 90% H2O/10% D2O
Schwieters, Kuszewski, Tjandra and Clore
calmodulin, capsaicin, METAL BINDING PROTEIN