Omega-Tbo-IT1: selective inhibitor of insect calcium channels isolated from Tibellus oblongus spider venom
omega-Tbo-IT1-New Inhibitor of Insect Calcium Channels Isolated from Spider Venom.
TWO-DIMENSIONAL 1H-1H DQF-COSY, TOCSY (80-MS MIXING TIME), NOESY (120-MS MIXING TIME) AND 1H-13C HSQC (AT NATURAL ABUNDANCE) NMR SPECTRA OF 1.5 MM RECOMBINANT OMEGA-TBO-IT1 TOXIN (SOLUBILIZED IN H2O OR D2O WITH 20 MM PHOSPHATE BUFFER, PH 5.8) WERE ACQUIRED AT 12C AND 20C ON NMR SPECTROMETER VARIAN NMR SYSTEM 700 MHZ.
simulated annealing, torsion angle dynamics
Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax