Solution structure of the analgesic sea anemone peptide APETx2
Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores.
Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels.
Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.
300 uM APETx2, 20 mM potassium phosphate, 95% H2O/5% D2O
Disulfide-rich toxin, Defensin fold, Toxin, ASIC3 blocker