RXFP1 utilises hydrophobic moieties on a signalling surface of the LDLa module to mediate receptor activation
The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.
chimera protein of the Low Density Liproprotein receptor (LDLR_Human, UNP P01130) and Relaxin receptor 1(RXFP1_HUMAN, UNP Q9HBX9).
Low-density lipoprotein receptor, Relaxin receptor 1
LDL receptor, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1
BACKBONE OF THE PROTEIN IS THE SECOND LIGAND BINDING DOMAIN OF HUMAN LDLR (LDLR_HUMAN, UNP RESIDUES 66-104 FROM P01130), REPLACED RESIDUES 69-81 WITH PEPTIDE FROM RELAXIN RECEPTOR 1 (RXFP1_HUMAN, UNP RESIDUES 28-39 FROM Q9HBX9)