Efficacy of an HIV-1 entry inhibitor targeting the GP41 fusion peptide
Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide.
Discovery and optimization of a natural HIV-1 entry inhibitor targeting the GP41 fusion peptide.
VIR-576 IS A NEW POLYPEPTIDE DESIGNED ON THE BASIS OF VIRIP [CELL 129 (2007) 263], A NATURAL POLYPEPTIDE THAT BINDS TO THE GP41 FUSION PEPTIDE OF HIV-1 PREVENTS THE VIRUS FROM ENTERING TARGET CELLS. VIR-576 WAS SELECTED AFTER A LONG SCREENING PROCESS BECAUSE IT SHOWS A CONSIDERABLE ENHANCED ACTIVITY.
Case, Darden, Cheatham, III, Simmerling, Wang, Duke, Luo, ... and Kollm
anti-viral polypeptide, gp41 Fusion Peptide, FP1-24, ANTIVIRAL PROTEIN